Beilstein J. Org. Chem.2010,6, No. 43, doi:10.3762/bjoc.6.43
Lukas J. Goossen Bettina Zimmermann Thomas Knauber Department of Chemistry, Organic Chemistry, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse, Geb. 54, D-67663 Kaiserslautern, Germany 10.3762/bjoc.6.43 Abstract A new protocol for the decarboxylative Heckvinylation of benzoic
arenes in good yields.
Keywords: carboxylic acids; copper; decarboxylation; Heckvinylation; palladium; Introduction
The palladium-catalyzed coupling of olefins with aryl or vinyl substrates, developed by Mizoroki [1] and Heck [2][3] in the 1970s, is one of the most important, reliable and generally
Büchner funnel, washed sequentially with ethanol (2 × 10 mL) and cold (0 °C) diethyl ether (10 mL), transferred to a round-bottomed flask, and dried at 2 × 10−3 mmHg to provide the corresponding potassium carboxylates 1a–i in 70–98% yield.
General procedure for the decarboxylative Heckvinylation
An oven
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Graphical Abstract
Scheme 1:
Proposed mechanism for the decarboxylative Heck reaction.